Population
Swiss mice (kidney and submaxillary gland genomic DNA)
Design
Preclinical
Authors
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May explain tissue-specific Ren expression in mice; leaves open relevance to human renin regulation in cardiovascular disease.
The study identifies structural divergence in the 5' regulatory sequences of mouse Ren1 and Ren2 genes, which may explain their differential expression in kidney and submaxillary glands.
Panthier et al. (1984) studied this question.
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