Population
(mRen2)27 transgenic rats [TGR(mRen2)27]
Comparison
Lisinopril vs Before lisinopril (baseline)
Design
Preclinical
Authors
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Challenges low-renin classification of the (mRen2)27 rat; leaves open its validity for modeling human hypertension.
The (mRen2)27 transgenic rat model has circulating active rat and mouse renin and prorenin, indicating it should not be considered a 'low renin' model.
Bohlender et al. (1998) studied this question.
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