Population
Adult Wistar-Kyoto rats
Comparison
Bilateral nephrectomy for 48 hours vs Controls (non-nephrectomized)
Design
Preclinical
Follow-up
48 hours
Authors
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Supports ANG-(1-12) as renin-independent cardiac precursor; hypothesis-generating for tissue angiotensin pathways in cardiorenal disease.
Bilateral nephrectomy in rats demonstrates that ANG-(1-12) can act as an alternate, renin-independent precursor for angiotensin peptide formation in cardiac tissue.
Ferrario et al. (2009) studied this question.
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