Key result
Ramipril reduced Ang II by 63% to 98% in plasma and most tissues, while nephrectomy decreased Ang II by 59% to 78% in tissues other than plasma and brain.
Why the study?
Does ramipril and/or nephrectomy alter the levels of angiotensin peptides in plasma and tissues of male Sprague-Dawley rats?
Population
Male Sprague-Dawley rats
Comparison
Ramipril, nephrectomy, or nephrectomy plus… vs Control rats
Design
Preclinical
Follow-up
24 to 48 hours
Authors
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Hypothesis-generating for non-renin/ACE Ang II pathways in rats; leaves open human relevance and precludes practice change.
Does ramipril and/or nephrectomy alter the levels of angiotensin peptides in plasma and tissues of male Sprague-Dawley rats?
While kidney-derived renin and ACE are primary drivers of Ang II formation, the persistence of Ang II in anephric and ramipril-treated rats suggests the existence of alternative, non-renin and non-ACE pathways for Ang II generation.
Campbell et al. (1993) studied this question. Ramipril and/or nephrectomy vs. Control rats was evaluated on Angiotensin peptide levels in plasma and tissues. Ramipril reduced Ang II by 63% to 98% in plasma and most tissues, while nephrectomy decreased Ang II by 59% to 78% in tissues other than plasma and brain.
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