January 1, 1997Clinical and Experimental Hypertension

Renal Tissue Angiotensins During Converting Enzyme Inhibition in the Spontaneously Hypertensive Rat

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Population

Adult male spontaneously hypertensive rats (SHR)

Design

Preclinical

Follow-up

14 days

Authors

MGM GrimaUniversity of Gondar CIC IngertCentre National de la Recherche Scientifique BMBruno MichelLaboratoire de Biophotonique et Pharmacologie

Discussion

Member takes

Implication

Animal data support independent circulating and tissue RAS regulation; leaves open translation to human ACE inhibitor effects.

Structured PICO

Population

Adult male spontaneously hypertensive rats (SHR)

Intervention

Ramipril given orally once daily for up to 14 days

Outcome

Renin activity (RA), angiotensin converting enzyme (ACE) activity and levels of angiotensin I (ang I) and angiotensin II (ang II) in the plasma, renal cortex and renal medulla at Day1 and Day14surrogate

The responses of plasma and kidney components of the renin-angiotensin system to ACE inhibition differ, suggesting independent regulation of circulating and tissue RAS.

Cite This Study

Grima et al. (1997) studied this question.

synapsesocial.com/papers/6a8852f6fc0635f4eccf0faf https://doi.org/10.3109/10641969709083178

Topics

Hypertension management

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Renal Tissue Angiotensins During Converting Enzyme Inhibition in the Spontaneously Hypertensive Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Renal Tissue Angiotensins During Converting Enzyme Inhibition in the Spontaneously Hypertensive Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider