Why the study?
Does short-term oral administration of ramipril inhibit ACE activity in human serum and tissue?
Population
Humans providing serum and tissue samples (renal cortex, heart, and blood vessels)
Comparison
Short-term oral administration of ramipril vs Normal range of ACE activity (baseline/untreated)
Design
Other
Follow-up
2 hours after last dosing
Authors
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Ramipril shows organ-specific tissue ACE inhibition in this model; leaves open clinical translation and human outcomes.
Does short-term oral administration of ramipril inhibit ACE activity in human serum and tissue?
Short-term oral treatment with ramipril almost completely inhibits ACE activity in the human renal cortex and arteries, demonstrating tissue ACE inhibition in humans for the first time.
Erman et al. (1991) studied this question.
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