Why the study?
Does brachial artery infusion of ramiprilat affect forearm blood flow in normotensive and hypertensive subjects?
Population
Normotensive volunteers and hypertensive subjects (n=12)
Comparison
Brachial artery infusions of ramiprilat… vs Pre-ramiprilat state (baseline)
Design
Other
Follow-up
30 minutes
Authors
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Local vascular ACE inhibition may contribute to ACEI hypotensive effects; confirms ACE presence in human resistance vessels but leaves mechanism open.
Does brachial artery infusion of ramiprilat affect forearm blood flow in normotensive and hypertensive subjects?
The study confirms the presence of ACE within human resistance vessels, suggesting that local vascular ACE inhibition contributes to the hypotensive action of ACE inhibitors.
Webb et al. (1986) studied this question.
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