Why the study?
Does ramiprilat induce coronary vasodilation via nitric oxide, bradykinin, and prostaglandins in an in vivo canine model?
Population
7 anesthetized dogs
Comparison
Ramiprilat infused directly into the left main… vs Baseline or absence of specific pretreatments
Design
Preclinical
Authors
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Supports NO-mediated epicardial and bradykinin-mediated microvascular ramiprilat effects in canines; hypothesis-generating for human coronary disease.
Does ramiprilat induce coronary vasodilation via nitric oxide, bradykinin, and prostaglandins in an in vivo canine model?
In a canine model, acute ramiprilat-induced vasodilation is mediated in part by nitric oxide in coronary conductance arteries and by bradykinin in resistance arteries.
Sudhir et al. (1996) studied this question.
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