Why the study?
Does ramipril therapy improve arterial responses to bradykinin in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats and normotensive Wistar-Kyoto rats
Comparison
Ramipril 1 mg kg-1 day-1 for 12 weeks vs Untreated hypertensive rats and untreated…
Design
Preclinical
Follow-up
12 weeks
Authors
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Hypothesis-generating for ACE inhibitor effects on endothelial kinin signaling in hypertension; leaves open human translation.
Does ramipril therapy improve arterial responses to bradykinin in spontaneously hypertensive rats?
Long-term ACE inhibition with ramipril improves endothelium-dependent arterial relaxation and potentiates B2-kinin receptor-mediated dilation in hypertensive rats.
Hutri‐Kähönen et al. (1997) studied this question.
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