Key result
Long-term treatment with ramipril significantly potentiated endothelium-dependent responses in the rat aorta by enhancing nitric oxide availability.
Why the study?
Does chronic ramipril treatment improve endothelial function in the aorta of normotensive rats?
Does chronic ramipril treatment improve endothelial function in the aorta of normotensive rats?
Chronic ACE inhibition with ramipril improves endothelial function in normotensive rats by increasing nitric oxide availability, an effect not seen with the direct vasodilator hydralazine.
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Caution against clinical extrapolation; extends preclinical evidence of ACE inhibitor endothelial effects in normotensive models.
Berkenboom et al. (1995) studied Normotensive. Ramipril vs. Saline solution (control) or hydralazine was evaluated on Endothelium-dependent relaxations induced by bradykinin, acetylcholine, and histamine. Long-term treatment with ramipril significantly potentiated endothelium-dependent responses in the rat aorta by enhancing nitric oxide availability.
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