November 1, 1993Hypertension

Long-term low-dose angiotensin converting enzyme inhibitor treatment increases vascular cyclic guanosine 3',5'-monophosphate.

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Why the study?

Does long-term ACE inhibitor treatment alter vascular function and cyclic GMP content in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats treated in utero and subsequently up to 20 weeks of age

Comparison

Ramipril or perindopril administered in utero… vs Untreated spontaneously hypertensive rats

Design

Preclinical

Follow-up

up to 20 weeks of age

Authors

PGPeter GohlkeShanghai Medical College of Fudan University VLV LambertyHeidelberg University IKIngo KuwerHeidelberg University

Discussion

Member takes

Implication

Hypothesis-generating for bradykinin-mediated vascular effects of ACE inhibitors in hypertension models; should not yet alter clinical practice.

Structured PICO

Does long-term ACE inhibitor treatment alter vascular function and cyclic GMP content in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats treated in utero and subsequently up to 20 weeks of age

Intervention

Ramipril (0.01 and 1 mg/kg per day) or perindopril (0.01 mg/kg per day) administered in utero and up to 20 weeks of age, with or without bradykinin B2-receptor antagonist Hoe 140

Comparator

Untreated spontaneously hypertensive rats (implied control)

Outcome

Functional changes in aortic preparations including aortic ACE activity, blood pressure, vasodilator/vasoconstrictor responses, and aortic cyclic GMP contentsurrogate

Long-term ACE inhibitor treatment alters vascular function of compliance vessels independently of antihypertensive action by increasing aortic cyclic GMP via bradykinin potentiation.

Cite This Study

Gohlke et al. (1993) studied this question.

synapsesocial.com/papers/6a8ffcedd68f3313dd83ff02 https://doi.org/10.1161/01.hyp.22.5.682

Topics

Hypertension management

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Implication

Hypothesis-generating for bradykinin-mediated vascular effects of ACE inhibitors in hypertension models; should not yet alter clinical practice.

Long-term low-dose angiotensin converting enzyme inhibitor treatment increases vascular cyclic guanosine 3',5'-monophosphate.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Long-term low-dose angiotensin converting enzyme inhibitor treatment increases vascular cyclic guanosine 3',5'-monophosphate.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider