Key result
Chronic enalapril augments endothelium-dependent relaxation in aortic rings from normotensive rats.
Why the study?
Does enalapril improve endothelium-dependent relaxations in normal rats?
Does enalapril improve endothelium-dependent relaxations in normal rats?
Chronic ACE inhibition with enalapril enhances the release of relaxing factors from the endothelium in normotensive rats.
Supports preclinical exploration of ACE inhibitors on endothelium; leaves open translation to human outcomes or practice.
The study was designed to evaluate the effects of chronic inhibition of angiotensin-converting enzyme (ACE) on the reactivity of the endothelium and the smooth muscle to vasoconstrictor and vasodilator stimuli in normal rats. Male rats were treated orally for 6 weeks with enalapril (10 mg/kg/day, n = 10) or with placebo (n = 10). Endothelium-dependent relaxations to acetylcholine and adenosine diphosphate were augmented in aortic rings from rats treated with enalapril compared with controls, whereas the response to the endothelium-independent vasodilator SIN-1 were similar. Contractions induced by phenylephrine and angiotensin II remained unchanged. Thus, the results suggest that chronic ACE inhibition enhances the release of relaxing factors from the endothelium in normotensive rats.
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Bossaller et al. (1992) studied Normotensive (n=20). Enalapril vs. Placebo was evaluated on Endothelium-dependent relaxations to acetylcholine and adenosine diphosphate. Chronic treatment with enalapril for 6 weeks augmented endothelium-dependent relaxations to acetylcholine and adenosine diphosphate in aortic rings from normotensive male rats.
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