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October 1, 1983Journal of Hypertension

Effect of Chronic Treatment with Captopril on Reactivity of Aortic Smooth Muscle from Normotensive and Renal Hypertensive Rats

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Why the study?

Does chronic captopril treatment attenuate alpha-adrenergic responsiveness of aortic rings in normotensive and renal hypertensive rats?

Population

Normotensive and renal hypertensive rats (bilateral renal encapsulation model)

Comparison

Captopril 48 mg/kg body weight per day for five… vs Untreated normotensive and untreated…

Design

Preclinical

Follow-up

5 weeks

Authors

DKDianne C. KiktaGraduate HospitalMFMelvin J. FreglyAmerican Association of Colleges of Pharmacy

Discussion

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Implication

May attenuate alpha-adrenergic vascular responses in rats independent of acute ACE inhibition; leaves open relevance to human hypertension therapy.

Structured PICO

Does chronic captopril treatment attenuate alpha-adrenergic responsiveness of aortic rings in normotensive and renal hypertensive rats?

P
Population
Normotensive and renal hypertensive rats (bilateral renal encapsulation model)
I
Intervention
Captopril 48 mg/kg body weight per day for five weeks
C
Comparator
Untreated normotensive and untreated hypertensive rats
O
Outcome
Contractile responses of aortic rings to vasoactive agents (norepinephrine, phenylephrine, isoproterenol, angiotensin I) in vitro after captopril washoutsurrogate

Chronic captopril treatment attenuates alpha-adrenergic responsiveness of rat aortic rings independent of acute ACE inhibition.

Cite This Study

Kikta et al. (1983) studied this question.

synapsesocial.com/papers/6a7d3de22935e92dbc775e32https://doi.org/10.1097/00004872-198310000-00011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of captopril on vascular reactivity of SHR in vivo and in vitro.1981 · 28 citations
  2. 2Effect of captopril on vasoconstriction and Ca2+ fluxes in aortic smooth muscle.1993 · 22 citations
  3. 3Effects of chronic administration of captopril on blood pressure and the renin-angiotensin-aldosterone system in normotensive rats.1983 · 9 citations
  4. 4The Influence of Chronic Captopril Treatment and its Withdrawal on Endothelium-Dependent Relaxation1992 · 15 citations
  5. 5An Experimental Study on the Effects of the Chronic Administration of an Angiotensin Converting Enzyme Inhibitor (Captopril) on Blood Pressure and the Renin-Angiotensin-Aldosterone System1980