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January 1, 1992Journal of Cardiovascular Pharmacology

Role of Endothelium-Derived Bradykinin in the Control of Vascular Tone

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Why the study?

Do ACE inhibitors modulate intracellular Ca2+ and endothelial autacoid formation in endothelial cells and isolated hearts?

Population

Human cultured endothelial cells, endothelium-intact bovine coronary arteries, and isolated perfused rabbit…

Comparison

ACE inhibitors vs Control/baseline or bradykinin alone

Design

Preclinical

Authors

MHMarkus HeckerUniversity of SaskatchewanTDThomas DambacherWestern Michigan UniversityRBRudi BusseVascular Medicine

Discussion

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Implication

May support bradykinin-mediated endothelial effects of ACE inhibitors; hypothesis-generating and leaves open human translation.

Structured PICO

Do ACE inhibitors modulate intracellular Ca2+ and endothelial autacoid formation in endothelial cells and isolated hearts?

P
Population
Human cultured endothelial cells, endothelium-intact bovine coronary arteries, and isolated perfused rabbit and rat hearts
I
Intervention
ACE inhibitors (ramiprilat 0.3 μM or moexiprilat 0.1-0.3 μM)
C
Comparator
Control/baseline or bradykinin alone
O
Outcome
Intracellular Ca2+ levels, endothelial autacoid formation (NO, PGI2), vascular cGMP content, and vascular tonesurrogate

ACE inhibitors enhance bradykinin-induced endothelial autacoid formation (NO and PGI2) by preventing kinin degradation, highlighting a mechanism for their vasodilatory effects.

Cite This Study

Hecker et al. (1992) studied this question.

synapsesocial.com/papers/6a86b86bbb0787ff27ca0417https://doi.org/10.1097/00005344-199200209-00011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelium-Derived Bradykinin1993 · 38 citations
  2. 2Potentiation by ACE inhibitors of the dilator response to bradykinin in the coronary microcirculation: interaction at the receptor level1994 · 97 citations
  3. 3Aniotensin-Converting Enzyme (ACE) Activity: Aortic ancf Endocardial Endothelium Compared1996 · 4 citations
  4. 4ACE inhibitor potentiation of bradykinin‐induced venoconstriction1997 · 60 citations
  5. 5Angiotensin-Converting Enzyme Inhibitor Ramiprilat Interferes With the Sequestration of the B 2 Kinin Receptor Within the Plasma Membrane of Native Endothelial Cells1999 · 114 citations