September 1, 1994Circulation

Attenuation of myocardial stunning by the ACE inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins but not nitric oxide.

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Why the study?

Does ramiprilat improve functional recovery of stunned myocardium through bradykinin, prostaglandins, or nitric oxide pathways in a dog model of ischemia-reperfusion?

Population

56 enflurane/N2O-anesthetized open-chest dogs subjected to 15 minutes of occlusion of the left circumflex…

Comparison

Ramiprilat administered before LCx occlusion… vs Placebo control, or HOE 140, indomethacin, or…

Design

Preclinical

Follow-up

4 hours of reperfusion

Authors

TEThomas EhringLMU Klinikum DBDietrich BaumgartMayo Clinic MKMladen KrajcarZabok General Hospital

Discussion

Member takes

Implication

Ramiprilat attenuates stunning via bradykinin-prostaglandin signaling in dogs; leaves open translation to human ischemia-reperfusion.

Structured PICO

Does ramiprilat improve functional recovery of stunned myocardium through bradykinin, prostaglandins, or nitric oxide pathways in a dog model of ischemia-reperfusion?

Population

56 enflurane/N2O-anesthetized open-chest dogs subjected to 15 minutes of occlusion of the left circumflex coronary artery (LCx) and 4 hours of subsequent reperfusion.

Intervention

Ramiprilat (20 micrograms/kg IV) administered before LCx occlusion, alone or in combination with bradykinin B2 receptor antagonist HOE 140, cyclooxygenase inhibitor indomethacin, or nitric oxide synthase inhibitor L-NAME.

Comparator

Placebo control, or HOE 140, indomethacin, or L-NAME alone.

Outcome

Systolic wall thickening (WT) and regional myocardial blood flow (BF) at 4 hours of reperfusion.surrogate

The attenuation of myocardial stunning by the ACE inhibitor ramiprilat is mediated by a signal cascade involving bradykinin and prostaglandins, but not nitric oxide.

Cite This Study

Ehring et al. (1994) studied this question.

synapsesocial.com/papers/6a740951acfb3e7ed3eafd75 https://doi.org/10.1161/01.cir.90.3.1368

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Attenuation of myocardial stunning by the ACE inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins but not nitric oxide.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Attenuation of myocardial stunning by the ACE inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins but not nitric oxide.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider