Why the study?
Does ramipril pretreatment improve myocardial protection against free radical injury in isolated rat hearts?
Population
Rats (Langendorff isolated hearts subjected to 1,1-diphenyl-2-picryl-hydrazyl free radical-induced injury)
Comparison
Ramipril (10 or 50 microg kg, i.v.) pretreatment… vs DPPH control group (no ramipril pretreatment)
Design
Preclinical
Follow-up
24, 48, and 72 hours post-pretreatment
Authors
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Ramipril may confer delayed protection in rat models; human translation and clinical relevance remain untested.
Does ramipril pretreatment improve myocardial protection against free radical injury in isolated rat hearts?
Ramipril induces delayed myocardial protection against free radical injury in rat hearts, sustained for 48 hours, via the bradykinin B2 receptor-NO pathway and protein synthesis.
Xiu Chen (1998) studied this question.
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