Why the study?
Does pretreatment with ramiprilat prevent free radical-induced cardiac injury in guinea-pig isolated hearts?
Population
Guinea-pig Langendorff perfused heart model subjected to free radical injury (superoxide anion or DPPH)
Comparison
Pretreatment with ramiprilat vs Exposure to free radical injury without…
Design
Preclinical
Authors
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Does not support clinical use; extends bradykinin-PKC-prostaglandin mechanisms in isolated hearts.
Does pretreatment with ramiprilat prevent free radical-induced cardiac injury in guinea-pig isolated hearts?
Ramiprilat provides cardioprotection against free radical injury in isolated guinea-pig hearts through a mechanism dependent on bradykinin B2 receptors, protein kinase C, and prostaglandins.
Xiu Chen (2000) studied this question.
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