Why the study?
Does ramipril reduce postoperative mortality in rats with left ventricular hypertrophy and myocardial infarction?
Population
Male Sprague Dawley rats with left ventricular hypertrophy and hypertension induced by aortic constriction…
Comparison
Ramipril 1 mg/kg/day via drinking water for 6… vs Untreated respective groups
Design
Preclinical
Follow-up
6 weeks
Authors
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Should not change human postoperative practice; hypothesis-generating for ACE inhibition in hypertensive LVH/MI models.
Does ramipril reduce postoperative mortality in rats with left ventricular hypertrophy and myocardial infarction?
In a rat model of LVH and MI, ACE inhibition with ramipril improved survival and myocardial metabolism.
Linz et al. (1996) studied this question.
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