Why the study?
Does ramipril improve coronary circulation in rats with pressure overload-induced left ventricular hypertrophy?
Does ramipril improve coronary circulation in rats with pressure overload-induced left ventricular hypertrophy?
In a rat model of pressure overload-induced left ventricular hypertrophy, ACE inhibition with ramipril reversed right but not left coronary vascular resistance, suggesting both hypertension and hypertrophy contribute to coronary impairment.
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Should not change LVH management; hypothesis-generating for hypertension versus hypertrophy effects on coronary beds.
Shimada et al. (2002) studied this question.
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