Why the study?
Does renin-angiotensin system blockade with ramipril or losartan regress left ventricular hypertrophy and improve survival in rats with pressure-overload hypertrophy?
Population
Rats with severe left ventricular hypertrophy induced by ascending aorta banding, characterized by normal…
Comparison
Ramipril or losartan administered during weeks 7… vs Vehicle or hydralazine administered during weeks…
Design
Preclinical
Follow-up
12 weeks after aortic banding (5 weeks of treatment)
Authors
Loading...
Supports RAS blockade in experimental pressure-overload LVH; leaves open translation to clinical hypertrophy.
Does renin-angiotensin system blockade with ramipril or losartan regress left ventricular hypertrophy and improve survival in rats with pressure-overload hypertrophy?
Blockade of the renin-angiotensin system with ramipril or losartan regresses cardiac hypertrophy and improves survival in a rat model of chronic pressure overload.
Bruckschlegel et al. (1995) studied this question.