Key result
Ramipril administration in patients with congestive heart failure increased global cardiac output by 27% (p<0.05) and increased or preserved regional blood flow despite hypotension.
Why the study?
Does ramipril improve global and regional hemodynamics in patients with congestive heart failure?
Population
11 patients with congestive heart failure, stabilized on digitalis, furosemide, and a fixed diet.
Comparison
Ramipril vs Baseline (2 control days prior to intervention)
Design
Cohort
Follow-up
7 weeks
Authors
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May enhance cardiac output and preserve regional perfusion in heart failure despite hypotension; hypothesis-generating and warrants randomized confirmation.
Does ramipril improve global and regional hemodynamics in patients with congestive heart failure?
Effect estimate: +27% increase
p-value: p=<0.05
In patients with congestive heart failure, ramipril improves cardiac output and preserves or increases regional blood flow to vital organs despite lowering systemic arterial pressure, leading to long-term clinical benefits.
Crozier et al. (1989) studied congestive heart failure (n=11). Ramipril vs. Baseline was evaluated on Global cardiac output (+27% increase, p=<0.05). Ramipril administration in patients with congestive heart failure increased global cardiac output by 27% (p<0.05) and increased or preserved regional blood flow despite hypotension.
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