Why the study?
Does ramipril alter hemodynamic parameters in patients with mild to moderate aortic stenosis and preserved left ventricular function?
Population
13 elderly patients with mild to moderate aortic stenosis, normal left ventricular and renal function, and…
Comparison
Ramipril titrated to a maximum dose of 7.5 mg… vs Baseline.
Design
Cohort, open-label
Follow-up
8 weeks
Authors
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Ramipril was not associated with hemodynamic changes in mild-moderate AS; leaves open long-term safety and requires randomized confirmation.
Does ramipril alter hemodynamic parameters in patients with mild to moderate aortic stenosis and preserved left ventricular function?
Short-term treatment with ramipril up to 7.5 mg twice daily is well tolerated and does not significantly alter hemodynamics in patients with mild to moderate aortic stenosis and preserved left ventricular function, challenging the presumed contraindication.
O’Brien et al. (2004) studied this question.
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