Key result
ACE inhibitors lower SBP ~19 mm Hg but increase mean pressure gradient in hypertensive AS.
Why the study?
The effects of ACE inhibitors in hypertensive patients with aortic valve stenosis were not well defined.
Do ACE inhibitors affect functional and haemodynamic variables in hypertensive patients with asymptomatic aortic valve stenosis?
Population
20 hypertensive patients with asymptomatic aortic valve stenosis, aged 73 (9) years
Comparison
Taking ACE inhibitors vs not taking ACE inhibitors
Design
Observational, drug withdrawal, single blinded study with randomisation of test order
Authors
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ACE inhibitors appear tolerable during exercise in hypertensive AS; small observational data leave open need for randomized confirmation.
RCT (n=20)
Single-blind
randomisation of the order of tests
Do ACE inhibitors affect functional and haemodynamic variables in hypertensive patients with asymptomatic aortic valve stenosis?
ACE inhibitors lower systolic blood pressure but increase mean pressure gradient in hypertensive patients with aortic stenosis, while favorably affecting stress hemodynamics.
Raed Aqel (2005) conducted an RCT in Hypertension and asymptomatic aortic valve stenosis (n=20). ACE inhibitors vs. Without ACE inhibitors was evaluated on Functional and haemodynamic variables while taking and not taking ACE inhibitors. ACE inhibitors lowered systolic blood pressure (140 vs 159 mm Hg, P=0.02) and increased mean pressure gradient (34 vs 28 mm Hg, P=0.037) in hypertensive patients with aortic valve stenosis.
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