Why the study?
Does ramipril suppress sympathetic nervous system activity and up-regulate alpha-adrenergic receptor responsiveness in older patients with mild to moderate hypertension?
Population
15 healthy older patients with mild to moderate hypertension
Comparison
Ramipril 5 mg to 20 mg for 8 weeks vs Placebo
Design
RCT, randomized, double-blind
Follow-up
8 weeks
Authors
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Ramipril does not suppress sympathetic activity in older hypertensives; challenges hypothesized ACE-inhibitor mechanism.
Does ramipril suppress sympathetic nervous system activity and up-regulate alpha-adrenergic receptor responsiveness in older patients with mild to moderate hypertension?
In older patients with mild to moderate hypertension, 8 weeks of ramipril therapy did not suppress systemic sympathetic nervous system activity or alter alpha-adrenergic responsiveness.
Lee et al. (1999) studied this question.
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