Why the study?
Does a single oral dose of ramipril 5 mg affect autonomic function in healthy young men?
Population
8 healthy male subjects, aged 22-26 years
Comparison
Ramipril 5 mg single oral administration vs Placebo
Design
RCT, Randomized crossover design, Double-blind
Follow-up
120 minutes
Authors
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Single-dose ramipril augments HRV in healthy men; extends evidence for acute vagal effects of ACE inhibition.
Does a single oral dose of ramipril 5 mg affect autonomic function in healthy young men?
A single 5 mg dose of ramipril enhances cardiac vagal tone without affecting sympathetic nervous activity in healthy young men.
Sugimoto et al. (1989) studied this question.
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