Why the study?
Does the lipophilic ACE inhibitor ramipril selectively influence autonomic neural function compared to the hydrophilic ACE inhibitor enalapril in essential hypertensive subjects?
Population
13 essential hypertensive subjects
Comparison
Ramipril monotherapy for 10 days vs Enalapril monotherapy for 10 days, and placebo…
Design
Other
Follow-up
10 days per treatment arm
Authors
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Enalapril and ramipril lower blood pressure equivalently without autonomic effects; challenges presumed selective influence of lipophilic agents.
Does the lipophilic ACE inhibitor ramipril selectively influence autonomic neural function compared to the hydrophilic ACE inhibitor enalapril in essential hypertensive subjects?
Lipophilic (ramipril) and hydrophilic (enalapril) ACE inhibitors similarly lower blood pressure without differentially affecting autonomic neural function in patients with essential hypertension.
Wu et al. (1994) studied this question.
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