Why the study?
Does a single oral dose of ramipril alter systemic and regional vascular responses to orthostatic stress in healthy volunteers?
Population
8 healthy volunteers
Comparison
Ramipril 5 mg single oral dose vs Placebo (crossover design)
Design
RCT, double-blind
Follow-up
150 minutes after administration and during LBNP
Authors
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Ramipril preserves renal hemodynamics without impairing orthostatic adaptation; confirms single-dose ACEI safety under simulated stress in healthy volunteers.
Does a single oral dose of ramipril alter systemic and regional vascular responses to orthostatic stress in healthy volunteers?
A single dose of ramipril preserves renal hemodynamics and does not interfere with adaptive vascular responses during simulated orthostatic stress in healthy volunteers.
Duranteau et al. (1995) studied this question.
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