Key result
In rats with experimental kidney failure, the addition of the ACE inhibitor ramipril prevented the deleterious effects of exogenous angiotensin 1-7 on blood pressure and cardiac fibrosis.
Why the study?
Does the addition of an ACE inhibitor to exogenous Ang 1-7 prevent adverse cardiac effects and unmask beneficial effects in rats with subtotal nephrectomy?
Does the addition of an ACE inhibitor to exogenous Ang 1-7 prevent adverse cardiac effects and unmask beneficial effects in rats with subtotal nephrectomy?
In a rat model of kidney disease, exogenous Ang 1-7 increases blood pressure and cardiac fibrosis, which is prevented by ACE inhibition, but combination therapy offers no additional cardiac benefits over ACE inhibition alone.
No takes yet. Share an insight, caveat, or question.
Does not support Ang 1-7 addition to ACE inhibitors in experimental kidney disease; leaves open human translation and net benefit.
Burrell et al. (2017) studied Experimental kidney failure (n=58). Angiotensin 1-7 and Ramipril vs. Vehicle was evaluated on Blood pressure, cardiac hypertrophy, and fibrosis. In rats with experimental kidney failure, the addition of the ACE inhibitor ramipril prevented the deleterious effects of exogenous angiotensin 1-7 on blood pressure and cardiac fibrosis.
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