Key result
Intravenous infusion of angiotensin-(1-7) in rats post-myocardial infarction attenuated hemodynamic impairment, highlighted by a 40% reduction in left ventricular end-diastolic pressure.
Why the study?
Does intravenous infusion of angiotensin-(1-7) improve hemodynamic parameters and endothelial function in a rat model of heart failure after myocardial infarction?
Does intravenous infusion of angiotensin-(1-7) improve hemodynamic parameters and endothelial function in a rat model of heart failure after myocardial infarction?
In a rat model of post-myocardial infarction heart failure, angiotensin-(1-7) infusion preserved cardiac and endothelial function, suggesting a potential mechanism for the cardiovascular benefits of ACE inhibitors.
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Supports further preclinical testing of angiotensin-(1-7) in heart failure; leaves open translation to patients.
Loot et al. (2002) studied Heart failure after myocardial infarction. Angiotensin-(1-7) vs. Saline was evaluated on Hemodynamic parameters and endothelial function. Intravenous infusion of angiotensin-(1-7) in rats post-myocardial infarction attenuated hemodynamic impairment, highlighted by a 40% reduction in left ventricular end-diastolic pressure.
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