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Editorial
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The authors challenge the commonly held view that ACE inhibitors increase angiotensin-(1-7) and that this peptide contributes to the actions of ACE inhibitors.
We read with interest the report by Loot et al 1 and the accompanying editorial 2 on the possible role of angiotensin-(1-7) in heart failure and cardiovascular regulation in general. It is also commonly stated (and repeated by Ferrario 2 ) that angiotensin converting-enzyme (ACE) inhibitors increase angiotensin-(1-7) and that angiotensin-(1-7) may contribute to the actions of ACE inhibitors. We believe that neither of these views may be valid.
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McMurray et al. (2002) studied this question.
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