Key result
Coronary artery ligation in rats led to elevated left ventricular end-diastolic pressures (25 vs 5 mm Hg; P<0.001) and increased expression of Ang-(1-7) restricted to cardiac myocytes.
Why the study?
Does myocardial infarction induced by coronary artery ligation alter the expression of Ang-(1-7) in the myocardium of rats?
Population
10-week-old Lewis rats (n=10 total; 5 ligated, 5 sham)
Comparison
Left coronary artery ligation to induce… vs Sham operation
Design
Preclinical
Follow-up
4 weeks
Authors
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Elevated post-MI Ang-(1-7) in rat myocytes is hypothesis-generating; leaves open its role in human ischemic HF and therapeutic potential.
Does myocardial infarction induced by coronary artery ligation alter the expression of Ang-(1-7) in the myocardium of rats?
Absolute Event Rate: 25% vs 5%
p-value: p=<0.001
In a rat model of ischemic cardiomyopathy, heart failure subsequent to coronary artery ligation leads to increased expression of Ang-(1-7) restricted to cardiac myocytes.
Averill et al. (2003) studied Ischemic Cardiomyopathy (n=10). Coronary artery ligation vs. Sham operation was evaluated on Left ventricular end-diastolic pressure (p=<0.001). Coronary artery ligation in rats led to elevated left ventricular end-diastolic pressures (25 vs 5 mm Hg; P<0.001) and increased expression of Ang-(1-7) restricted to cardiac myocytes.
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