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January 27, 2010Circulation Heart FailureOpen Access

Circulating Rather Than Cardiac Angiotensin-(1-7) Stimulates Cardioprotection After Myocardial Infarction

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Why the study?

Does circulating Angiotensin-(1-7) improve cardiac function and stimulate cardiovascular regeneration after myocardial infarction in rodents?

Population

Rodents (rats, mice deficient for Mas receptor, and mice overexpressing Ang- exclusively in the heart) with…

Comparison

Angiotensin- either produced locally in the… vs Sham or infarcted rodents without treatment, or…

Design

Preclinical

Follow-up

3 weeks

Authors

YWYong WangUnion HospitalCQCheng QianSoochow UniversityARAnton J.M. RoksErasmus MC

Discussion

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Implication

Supports circulating Ang-(1-7) for post-MI repair in rodents; leaves open translation to human trials.

Structured PICO

Does circulating Angiotensin-(1-7) improve cardiac function and stimulate cardiovascular regeneration after myocardial infarction in rodents?

P
Population
Rodents (rats, mice deficient for Mas receptor, and mice overexpressing Ang-(1-7) exclusively in the heart) with myocardial infarction induced by permanent coronary artery occlusion
I
Intervention
Angiotensin-(1-7) either produced locally in the heart or subcutaneously injected
C
Comparator
Sham or infarcted rodents without treatment, or treated with Mas receptor blocker A779
O
Outcome
Proliferation of endothelial progenitor cells, cardiac hypertrophy, and cardiac function at 3 weeks after MIsurrogate

Circulating, but not locally produced cardiac Ang-(1-7), improves cardiac function and stimulates cardiac progenitor cells after myocardial infarction in rodents.

Cite This Study

Wang et al. (2010) studied this question.

synapsesocial.com/papers/6a6fb6516ceb2bbd16dfb79dhttps://doi.org/10.1161/circheartfailure.109.905968

Topics

HFrEF treatmentHeart failure
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