Population
Endothelial progenitor cells (EPCs) isolated from peripheral blood
Comparison
Angiotensin II (Ang II) exposure (100 nmol/l) vs Control and/or pre-treatment with valsartan or…
Design
Preclinical
Follow-up
14 days in culture
Authors
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Hypothesis-generating for AT1 blockade preserving EPC function; leaves open translation to human cardiovascular outcomes.
Angiotensin II accelerates endothelial progenitor cell senescence and impairs proliferation via oxidative stress, effects that can be mitigated by AT1 receptor blockade with valsartan.
Imanishi et al. (2005) studied this question.
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