March 1, 2000Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Angiotensin II Stimulates Endothelial Vascular Cell Adhesion Molecule-1 via Nuclear Factor-κB Activation Induced by Intracellular Oxidative Stress

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Population

Endothelial cells

Design

Preclinical

Authors

MPMaría E. PueyoUniversity of the Basque Country WGWalter G. GonzalezHalliburton (United Kingdom)ANAntonino NicolettiInserm

Discussion

Member takes

Implication

Supports Ang II-oxidative pathways in atherogenesis; extends mechanistic data but leaves open in vivo and clinical relevance.

Structured PICO

Population

Endothelial cells

Intervention

Angiotensin II

Outcome

VCAM-1 mRNA and protein expressionsurrogate

Angiotensin II promotes early atherogenic changes in endothelial cells by inducing intracellular oxidative stress and upregulating VCAM-1 via NF-kappaB.

Cite This Study

Pueyo et al. (2000) studied this question.

synapsesocial.com/papers/69ffef6d6018b8d0892da049 https://doi.org/10.1161/01.atv.20.3.645

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Angiotensin II Stimulates Endothelial Vascular Cell Adhesion Molecule-1 via Nuclear Factor-κB Activation Induced by Intracellular Oxidative Stress

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Stimulates Endothelial Vascular Cell Adhesion Molecule-1 via Nuclear Factor-κB Activation Induced by Intracellular Oxidative Stress

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider