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September 14, 1999Circulation

Angiotensin II Induces Vascular Cell Adhesion Molecule-1 Expression In Rat Vasculature

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Why the study?

Does Angiotensin II increase VCAM-1 expression in rat vasculature?

Population

Rats and cultured rat aortic smooth muscle cells (RASMCs)

Comparison

Angiotensin II infusion for 6 days and Ang II… vs Norepinephrine infusion for 6 days (in vivo)

Design

Preclinical

Follow-up

6 days

Authors

PTPradyumna E. TummalaUniversity of California, IrvineXCXilin ChenShanghai University of Engineering ScienceCSCynthia L. SundellRutgers, The State University of New Jersey

Discussion

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Implication

Hypothesis-generating for Ang II in vascular inflammation; leaves open translation to human atherosclerosis or practice change.

Key Points

  • This research aims to explore whether angiotensin II contributes to atherosclerosis by upregulating VCAM-1 expression.
  • Rats were infused with norepinephrine or Ang II for 6 days to evaluate hypertensive responses.
  • Losartan treatment (50 mg/kg/day) was administered to assess its effect on hypertension and VCAM-1 expression.
  • Cultured rat aortic smooth muscle cells were used to evaluate VCAM-1 mRNA expression and NF-kappaB activation.
  • Ang II treatment significantly increased aortic VCAM-1 protein and mRNA expression compared to norepinephrine-infused rats.
  • Losartan inhibited Ang II-induced hypertension and VCAM-1 mRNA expression.
  • NF-kappaB activation was correlated with increased VCAM-1 promoter transactivation in the presence of Ang II.

Structured PICO

Does Angiotensin II increase VCAM-1 expression in rat vasculature?

P
Population
Rats and cultured rat aortic smooth muscle cells (RASMCs)
I
Intervention
Angiotensin II (Ang II) infusion for 6 days (in vivo) and Ang II treatment (in vitro), with or without oral losartan (50 mg. kg(-1). d(-1)), proteasome inhibitors, or IkappaB-alpha overexpression
C
Comparator
Norepinephrine infusion for 6 days (in vivo)
O
Outcome
Aortic VCAM-1 protein and mRNA expressionsurrogate

Angiotensin II induces vascular inflammation by upregulating VCAM-1 via NF-kappaB pathways, suggesting a molecular mechanism for its contribution to atherogenesis.

Cite This Study

Tummala et al. (1999) studied this question.

synapsesocial.com/papers/6a200a8a35281a23f90dd66bhttps://doi.org/10.1161/01.cir.100.11.1223

Topics

Hypertension management
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Also Consider

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  1. 1Plasma renin activity and coronary heart disease: are they related?1995 · 8 citations
  2. 2Monocyte Chemoattractant Protein-1 Expression in Aortic Tissues of Hypertensive Rats1997 · 224 citations
  3. 3Association of the Renin-Sodium Profile with the Risk of Myocardial Infarction in Patients with Hypertension1991 · 735 citations
  4. 4In defense of alternative antihypertensive therapy.1988 · 10 citations
  5. 5Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells.1992 · 359 citations