June 23, 2000Circulation Research

Angiotensin II Activates Nuclear Transcription Factor κB Through AT1and AT2in Vascular Smooth Muscle Cells

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Population

Rat vascular smooth muscle cells

Design

Preclinical

Authors

MRMarta Ruiz‐OrtegaVascular / Pulmonary Vascular ÓLÓscar LorenzoDiabetes Australia MRMónica RupérezUniversidad Autónoma de Madrid

Discussion

Member takes

Implication

Supports dual AT1/AT2 mediation in vascular cells; hypothesis-generating and should not yet change practice.

Structured PICO

Population

Rat vascular smooth muscle cells

Intervention

Angiotensin II (Ang II) and AT1/AT2 receptor antagonists/agonists

Outcome

NF-kappaB DNA binding, nuclear translocation, and transcription activitysurrogate

Angiotensin II activates NF-kappaB in vascular smooth muscle cells via both AT1 and AT2 receptors, suggesting a role for AT2 in vascular pathobiology.

Cite This Study

Ruiz‐Ortega et al. (2000) studied this question.

synapsesocial.com/papers/6a6f2ff7660549caf2c3bf67 https://doi.org/10.1161/01.res.86.12.1266

View Full Paper

Ask AI

Bookmark

Angiotensin II Activates Nuclear Transcription Factor κB Through AT1and AT2in Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Activates Nuclear Transcription Factor κB Through AT1and AT2in Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider