November 16, 2004Hypertension
Angiotensin-(1–7) Attenuates Neointimal Formation After Stent Implantation in the Rat
Why the study?
Does angiotensin-(1-7) infusion reduce neointimal formation and improve endothelial function after stent implantation in a rat model?
Population
Male Wistar rats undergoing stent implantation in the abdominal aorta or sham surgery
Comparison
Angiotensin- infusion via osmotic minipump for 4… vs Saline administration via osmotic minipump
Design
Preclinical
Follow-up
4 weeks
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for angiotensin-(1-7) in preventing restenosis; human trials required before any clinical consideration.
Structured PICO
Does angiotensin-(1-7) infusion reduce neointimal formation and improve endothelial function after stent implantation in a rat model?
P
Population
Male Wistar rats undergoing stent implantation in the abdominal aorta or sham surgery
I
Intervention
Angiotensin-(1-7) infusion (24 microg/kg per hour) via osmotic minipump for 4 weeks
C
Comparator
Saline administration via osmotic minipump
O
Outcome
Neointimal formation (thickness, area, percentage stenosis) and endothelial function at 4 weekssurrogate
Angiotensin-(1-7) attenuates neointimal formation and improves endothelial function following stent implantation in a rat model, suggesting potential therapeutic value for preventing in-stent restenosis.
Cite This Study
Langeveld et al. (2004) studied this question.