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August 9, 2005HypertensionOpen Access

Short-Term Angiotensin(1-7) Receptor Mas Stimulation Improves Endothelial Function in Normotensive Rats

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Why the study?

Does short-term stimulation of angiotensin(1-7) receptors improve endothelial function in normotensive rats?

Population

Conscious adult male Wistar rats

Comparison

Infusion of angiotensin or its nonpeptide analog… vs Vehicle and baseline measurements before infusion

Design

Preclinical

Follow-up

30 minutes

Authors

RFRaphael Faria-SilvaUniversidade Federal de Minas GeraisFDFernanda V. DuarteUniversidade Federal de Minas GeraisRSRobson A.S. SantosGeneral Cardiology

Discussion

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Implication

Hypothesis-generating for Ang(1-7) receptor agonism in endothelial function; should not yet inform clinical practice.

Structured PICO

Does short-term stimulation of angiotensin(1-7) receptors improve endothelial function in normotensive rats?

P
Population
Conscious adult male Wistar rats
I
Intervention
Infusion of angiotensin(1-7) (0.7 and 7.0 pmol/min) or its nonpeptide analog AVE 0991 (11, 45, and 230 pmol/min)
C
Comparator
Vehicle (6 microL/min) and baseline measurements before infusion
O
Outcome
Hypotensive effect of acetylcholine or sodium nitroprusside (change in mean arterial pressure)surrogate

Short-term stimulation of angiotensin(1-7) receptors with angiotensin(1-7) or AVE 0991 improves endothelial function in normotensive rats by facilitating nitric oxide release.

Cite This Study

Faria-Silva et al. (2005) studied this question.

synapsesocial.com/papers/6a7637c61ee3153e8f614213https://doi.org/10.1161/01.hyp.0000174594.17052.33
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential baroreceptor reflex modulation by centrally infused angiotensin peptides1992 · 155 citations
  2. 2Production of angiotensin-(1-7) by human vascular endothelium.1992 · 153 citations
  3. 3Angiotensin-(1–7) Attenuates Neointimal Formation After Stent Implantation in the Rat2004 · 100 citations
  4. 4Potentiation of Bradykinin by Angiotensin-(1-7) on Arterioles of Spontaneously Hypertensive Rats Studied In Vivo2001 · 122 citations
  5. 5Role of Angiotensin-(1-7) in the Modulation of the Baroreflex in Renovascular Hypertensive Rats1997 · 93 citations