Population
Preclinical models including Mas-deficient mice, mouse kidneys, Mas-transfected cells, and Mas-deficient…
Design
Preclinical
Authors
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Mas deletion effects in mice warrant no clinical practice change; leaves open human receptor validation and therapeutic targeting.
This basic science study identifies the G protein-coupled receptor Mas as the functional endogenous receptor for Angiotensin-(1-7), providing a molecular basis for its physiological actions.
Santos et al. (2003) studied this question.
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