Key result
Angiotensin 1-7 counteracts Angiotensin II to promote cardiovascular protection via the Mas receptor and nitric oxide.
This review highlights the functional role and molecular pathways of Ang-(1-7) and its Mas receptor in mediating smooth muscle relaxation and cardioprotection.
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Supports Ang-(1-7)/Mas pathway exploration in hypertension; leaves open clinical translation pending randomized trials.
Ang-(1-7) is produced via degradation of Ang II by the human angiotensin converting enzyme, also known as ACE2. In the cardiovascular system, Ang-(1-7) has been shown to produce effects that are opposite to those of Ang II. These include smooth muscle relaxation and cardioprotection. While the roles of Ang-(1-7) in other systems are currently topic of intense research, functional data suggest a relaxation action in gastrointestinal smooth muscles in a way that corroborates the results obtained from vascular tissues. However, more studies are necessary to determine a relevant role for Ang-(1-7) in the gastrointestinal system. The Ang-(1-7) actions are mediated by a distinct, functional, Ang-(1-7) receptor: the Mas receptor as shown by diverse studies involving site-specific binding techniques, selective antagonists, and targeted gene deletion. This paper provides an overview of the functional role and the molecular pathways involved in the biosynthesis and activity of Ang-(1-7) in diverse systems.
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Godoy et al. (2011) conducted a review in Cardiovascular and Gastrointestinal Smooth Muscle Physiology. Angiotensin-(1-7) was evaluated. Angiotensin-(1-7) counteracts the effects of Angiotensin II by promoting smooth muscle relaxation and cardiovascular protection through interactions with the Mas receptor and nitric oxide release.
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