Key result
The ACE2/Ang-(1-7)/Mas axis acts as an endogenous counterregulatory pathway within the renin-angiotensin system, opposing the vasoconstrictor and proliferative effects of ACE, Ang II, and AT1.
Design
Review
Authors
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Supports ACE2/Ang-(1-7)/Mas modulation in CV/renal disease; leaves open clinical translation pending trials.
This review highlights the ACE2/Ang-(1-7)/Mas axis as a crucial counterregulatory mechanism to the classical renin-angiotensin system, with significant implications for cardiovascular and renal physiology.
Santos et al. (2012) reported a review. ACE2/Ang-(1-7)/Mas axis was evaluated. The ACE2/Ang-(1-7)/Mas axis acts as an endogenous counterregulatory pathway within the renin-angiotensin system, opposing the vasoconstrictor and proliferative effects of ACE, Ang II, and AT1.
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