Key result
The ACE2-Ang(1-7)-Mas axis acts as a putative ACE-Ang II-AT(1) receptor counter-regulatory axis within the renin-angiotensin system.
Design
Review
Authors
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Broadens RAS conceptualization for clinicians; leaves open targeted therapies pending prospective trials.
The identification of the ACE2-Ang(1-7)-Mas axis expands the understanding of the renin-angiotensin system beyond a simple linear cascade to a complex system with counter-regulatory pathways.
Santos et al. (2008) reported a review. ACE2-Ang(1-7)-Mas axis was evaluated. The ACE2-Ang(1-7)-Mas axis acts as a putative ACE-Ang II-AT(1) receptor counter-regulatory axis within the renin-angiotensin system.
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