Why the study?
Does ramipril improve renal ACE2 expression in rats with acute kidney injury induced by subtotal nephrectomy?
Population
Rats with acute kidney injury induced by subtotal nephrectomy (STNx) and Control rats
Comparison
Ramipril 1 mg/kg of body weight/day vs Vehicle
Design
Preclinical
Follow-up
10 days
Authors
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Hypothesis-generating in rodent AKI; leaves open whether ACE2 modulation translates to human renoprotection.
Does ramipril improve renal ACE2 expression in rats with acute kidney injury induced by subtotal nephrectomy?
ACE inhibition with ramipril ameliorates the reduction in renal ACE2 activity observed in acute kidney injury, potentially contributing to its renoprotective effects.
Velkoska et al. (2009) studied this question.
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