Key result
In a mouse model of early chronic kidney disease, ACE2 inhibition significantly increased albuminuria via an AT(1) receptor-dependent mechanism, whereas ANG-(1-7) did not affect albuminuria.
Endogenous ACE2 appears renoprotective in early chronic kidney disease, as its inhibition exacerbates albuminuria via an AT1 receptor-dependent mechanism.
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ACE2 inhibition worsens albuminuria in CKD mice; leaves open whether modulation offers renoprotection in human disease.
Dilauro et al. (2010) studied Chronic kidney disease. ACE2 inhibitor MLN-4760 or ANG-(1-7) vs. Vehicle or Sham was evaluated on Albuminuria, blood pressure, and FITC-inulin clearance. In a mouse model of early chronic kidney disease, ACE2 inhibition significantly increased albuminuria via an AT(1) receptor-dependent mechanism, whereas ANG-(1-7) did not affect albuminuria.
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