Population
50 Wistar rats with streptozotocin-induced diabetic nephropathy, and cultured glomerular mesangial cells
Comparison
Adenoviral-ACE2 overexpression, ACE inhibition… vs No treatment, Ad-green fluorescent protein, and…
Design
Preclinical, randomly divided
Follow-up
4 weeks after treatment
Authors
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ACE2 overexpression matches ACEI renoprotection in diabetic rat nephropathy without combination benefit; leaves open clinical translation.
ACE2 overexpression exerts renoprotective effects similar to ACE inhibition in a rat model of diabetic nephropathy, with no additive benefit from combination therapy.
Liu et al. (2010) studied this question.
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