Key result
Recombinant human ACE2 prevented Ang II-induced hypertension, renal oxidative stress, and tubulointerstitial fibrosis in Ang II-infused mice.
Why the study?
Does recombinant human ACE2 prevent Angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis in mice?
Does recombinant human ACE2 prevent Angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis in mice?
Recombinant human ACE2 protects against Angiotensin II-induced hypertension and renal injury, suggesting a potential therapeutic role in kidney disease.
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Supports ACE2 as renoprotective in Ang II models; leaves open translation to clinical hypertension management.
Zhong et al. (2010) studied Angiotensin II-induced renal disease. Recombinant human ACE2 vs. Ang II-infused wild-type mice was evaluated on Renal Ang II levels, oxidative stress, and tubulointerstitial fibrosis. Recombinant human ACE2 prevented Ang II-induced hypertension, renal oxidative stress, and tubulointerstitial fibrosis in Ang II-infused mice.
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