Key result
Induced myocardial infarction in rats significantly increased plasma renin (27.4 vs 7.5 ng ANG I/ml/h, P<0.0002) and myocardial renin (8.8 vs 2.5 ng ANG I/g/h, P<0.008) compared to sham controls.
Why the study?
Does myocardial infarction alter renin and angiotensinogen levels in plasma and myocardium in rats?
Population
Rats with induced myocardial infarction involving 45 +/- 4% of left ventricular circumference with…
Comparison
Induced myocardial infarction vs Sham controls
Design
Preclinical
Follow-up
10 days
Authors
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Rat MI elevates myocardial renin; hypothesis-generating for local RAS in remodeling, with no clinical implications yet.
Does myocardial infarction alter renin and angiotensinogen levels in plasma and myocardium in rats?
Absolute Event Rate: 27.4% vs 7.5%
p-value: p=<0.0002
Myocardial renin increases after infarction in proportion to plasma renin and infarct size, while myocardial angiotensinogen is maintained despite decreased plasma levels.
Hirsch et al. (1999) studied Myocardial infarction (n=22). Myocardial infarction vs. Sham controls was evaluated on Plasma renin (ng ANG I. ml plasma. h-1) (p=<0.0002). Induced myocardial infarction in rats significantly increased plasma renin (27.4 vs 7.5 ng ANG I/ml/h, P<0.0002) and myocardial renin (8.8 vs 2.5 ng ANG I/g/h, P<0.008) compared to sham controls.
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