Key result
Myocardial infarction in rats resulted in a 4-, 14-, and 8-fold increase in renin mRNA in the infarcted left ventricle at 2, 4, and 7 days after surgery, respectively (P < 0.05).
Population
Wistar-Kyoto rats undergoing myocardial infarction (MI) or sham surgery
Comparison
Myocardial infarction (MI) surgery vs Sham surgery
Design
Preclinical
Follow-up
1 to 90 days
Authors
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Post-MI cardiac RAS mRNA upregulation in rats; leaves open translation to human remodeling or therapy.
Effect estimate: 4-, 14-, and 8-fold increase in renin mRNA
p-value: p=< 0.05
The localized increase in renin mRNA in the infarct border zone suggests a role for intracardiac angiotensin II in infarct healing, rather than in the development of post-MI cardiac hypertrophy.
Passier et al. (1996) studied Myocardial infarction. Myocardial infarction surgery vs. Sham surgery was evaluated on Renin and angiotensinogen mRNA contents (4-, 14-, and 8-fold increase in renin mRNA, p=< 0.05). Myocardial infarction in rats resulted in a 4-, 14-, and 8-fold increase in renin mRNA in the infarcted left ventricle at 2, 4, and 7 days after surgery, respectively (P < 0.05).
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