What does this research mean for the field?

Following left ventricular myocardial infarction, regional increases in cardiac hormone and contractile protein mRNA occur in similar subchamber regions, suggesting mutual activation by mechanical or neuroendocrine stimuli during the transcriptional response to myocardial overload. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1998Cardiovascular ResearchOpen Access

Altered cardiac hormone and contractile protein messenger RNA levels following left ventricular myocardial infarction in the rat: an in situ hybridization histochemical study

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Population

Wistar rats

Comparison

Left ventricular myocardial infarction produced… vs Sham-operated rats

Design

Preclinical

Follow-up

4 weeks

Authors

RYRichard L. YoungSouth Australian Health and Medical Research Institute

Discussion

Member takes

Implication

Does not inform post-MI patient management; extends mechanistic evidence of gene expression changes in rodent ventricular overload.

Structured PICO

Population

Wistar rats

Intervention

Left ventricular myocardial infarction (LVMI) produced by ligation of the left anterior descending coronary artery

Comparator

Sham-operated rats

Outcome

Spatiotemporal expression of cardiac contractile protein and peptide hormone mRNA (sACT, MLC-2v, beta-MHC, and ppANP) at 24 h, 1 and 4 weeks post-LVMIsurrogate

Regional increases in cardiac hormone and contractile protein mRNA post-LVMI in rats suggest mutual activation by mechanical or neuroendocrine stimuli in response to myocardial overload.

Cite This Study

Richard L. Young (1998) studied this question.

synapsesocial.com/papers/6a1bcd690a1f7575939cf2ab https://doi.org/10.1016/s0008-6363(97)00205-8

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Ask AI

Bookmark

Altered cardiac hormone and contractile protein messenger RNA levels following left ventricular myocardial infarction in the rat: an in situ hybridization histochemical study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Altered cardiac hormone and contractile protein messenger RNA levels following left ventricular myocardial infarction in the rat: an in situ hybridization histochemical study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider