Key result
Coronary artery ligation in rats induced a shift in myosin isoenzyme distribution and depressed actomyosin ATPase activity by 3 weeks, with left ventricular V1 myosin decreasing by 18%.
Why the study?
Does myocardial infarction induce regional variability in cardiac actomyosin ATPase activity and myosin isoenzymes in rats?
Population
Rats (infarcted and sham-operated models)
Comparison
Myocardial infarction induced by coronary artery… vs Sham operation
Design
Preclinical
Follow-up
3 and 11 weeks
Authors
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Rat MI model data are preclinical; leaves open myosin shifts' role in human post-MI remodeling.
Does myocardial infarction induce regional variability in cardiac actomyosin ATPase activity and myosin isoenzymes in rats?
Myocardial infarction in rats induces early (by 3 weeks) regional shifts in myosin isoenzyme distribution and depressed ATPase activity that persist without further deterioration up to 11 weeks.
Geenen et al. (1989) studied Myocardial infarction. Coronary artery ligation vs. Sham operation was evaluated on Regional variability in cardiac actomyosin adenosine triphosphate (ATPase) activity and myosin isoenzymes. Coronary artery ligation in rats induced a shift in myosin isoenzyme distribution and depressed actomyosin ATPase activity by 3 weeks, with left ventricular V1 myosin decreasing by 18%.
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